Senior Purification Scientist

At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - To enable our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies.

Our work in specialty diagnostics - from providing diagnostic assays and instruments to clinical monitoring across disease stages - improves the diagnosis and management of blood cancers and immune system disorders. Your determination to put patients at the heart of every decision will improve health outcomes that people and communities depend on - now and in the future.

Location/Division Specific Information
The Binding Site Group, part of Thermo Fisher Scientific, is a global leader in specialty diagnostics, provides diagnostic assays and instruments to improve the diagnosis and management of blood cancers and immune system disorders. The Binding Site's Freelite® offering is widely recommended for multiple myeloma diagnosis and monitoring across all stages of the disease by major clinical guideline publications. In addition, The Binding Site is an active and influential contributor to the broader scientific community. To find out more visit www.bindingsite.com

Discover Impactful Work:
The post holder will be responsible for:Assessing all technical and practical aspects of existing purification strategies and driving process improvements throughout the manufacturing teams to improve the quality and efficiency of product manufacture.Critically analyse production equipment and drive improvements to equipment selection and process design to maximise manufacturing performance.To participate in process development and transfer into manufacturing to maximise manufacturing performance.

A Day in the Life:
Lead the investigation, assessment and review of current purification manufacturing strategies.Lead process data collection, analysis and interpretation. Autonomy to Drive process improvements to yield and process performance in the current supply of intermediate protein reagents, focusing where required on alternative strategies and solutions to existing challengesLead the assessment of current equipment capabilities, driving improvements in technology to align with best-in-class industry standards.Developing and leveraging expertise across the organization - instrumental in developing future manufacturing strategies to manufacture best in class biological reagents.Assessment of new product introduction to ensure best industry practice is in use.Assessment of non-conformance and CAPA to ensure best in class resolution of processing challenges.

EducationDegree in Biochemistry or equivalent scientific subject and/or higher degree in protein / immunoglobulin purification based research.

ExperienceCandidate must have significant experience in protein purification techniques, with an expectation of at least 10 years' experience at large laboratory / pilot scale manufacturing.Demonstrated ability to lead Projects either through experience or recognised project management training.

Knowledge, Skills, AbilitiesDemonstrated knowledge of modern chromatography techniques, strategies and equipmentDemonstrated knowledge of protein biochemistry to drive process improvements.Thorough understanding of concentration / diafiltration techniques and equipmentExperience of liaising with Key industry suppliers of purification technologyDetailed understanding of purification process and equipment validationProject management

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